Abstract
Botanicals contain a great diversity of compounds that exhibit wide variation in their physicochemical properties. Although no single analytical method is available to measure all potentially active components, HPLC with charged aerosol detection is a nearly universal approach that nonselectively measures any nonvolatile and many semivolatile compounds; that is, charged aerosol detection does not require that analytes be ionizable (as required for MS) or contain a chromophore (as required for UV). Furthermore, all non-volatile analytes produce similar response independent of chemical structure, enabling estimation of relative abundance when external standards are lacking.
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