Abstract
Botanicals contain a great diversity of compounds that exhibit wide variation in their physicochemical properties. Although no single analytical method is available to measure all potentially active components, HPLC with charged aerosol detection is a nearly universal approach that nonselectively measures any nonvolatile and many semivolatile compounds; that is, CAD does not require that analytes be ionizable (as required for mass spectrometry) or contain a chromophore (as required for UV spectrophotometry).
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