Abstract
A series of C 3-symmetric triprolinamide catalysts based on triphenyl- and tribenzylphosphine oxide has been developed to catalyze the direct asymmetric aldol reaction of aromatic aldehydes and cyclohexanone. Under the optimal conditions, high isolated yield (up to 96%), diastereoselectivities (up to 88:12) and enantio-selectivities (up to 97% ee) were obtained.
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