Abstract
Cytotrienins A and B, two novel triene-ansamycins containing a unique 1-aminocyclopropane carboxylic acid moiety, were isolated from the culture broth of Streptomyces sp. through a separation procedure guided by the cytotoxic activity in vitro. The structures were elucidated on the basis of spectroscopic data. Cytotrienins A and B exhibited a potent apoptosis-inducing activity on human leukemia HL-60 cells.
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