Novel Synthesis of Pyrrolo [2,3-d] pyrimidines Bearing Sulfonamide Moieties as Potential Antitumor and Radioprotective Agents

Abstract

A novel series of pyrrolo[2,3-d] pyrimidines bearing sulfonamide moieties have been synthesized and tested for their antitumor activity. Among them, compounds 4, 8b, Bd, 8g and 14 showed promising antitumor activity. Moreover, compound 8d exhibited radioprotective activity. The structures of the newly synthesized compounds were established by their elemental analyses and spectral data.