Abstract

The 3,3,3-trifluoroprop-1-en-2-yl-substituted furans ( 4) were synthesized via palladium-catalyzed cyclization–isomerization of 1,1,1-trifluoro-2-[( tert-butyldimethylsilyloxy)methyl]-3-alkynylbut-2-en-1-ols ( 3), which were readily obtained from 1,1,1-trifluoro-2-[( tert-butyldimethylsilyloxy)methyl]-3,3-dibromoprop-2-ene ( 1) in three steps.

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