Abstract
The development and designing of self-testing blood-glucose electrochemical biosensor is an effective approach for diabetic patients to overcome and control this high health concerning issue. Herein, we successfully designed novel single-walled carbon nanotubes-porous silicon nanocomposites framework (SWCNTs-PSi NCs) via simple stain etching and ultrasonication techniques. X-ray Diffraction (XRD), Raman spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Field Emission Scanning Electron Microscopy (FESEM), Transmission Electron Microscopy (TEM), Energy-Dispersive Spectroscopy (EDS), and X-ray Photoelectron Spectroscopy (XPS) were employed to study the porous morphology with ~30 nm pore size and overall structural characterization of the SWCNTs-PSi NCs. This newly fabricated SWCNTs-PSi modified glassy carbon electrode (GCE) biosensor can measure an extremely wide range of glucose (0.5–28.5 mM) in phosphate buffer solution (PBS) compared to the regular glucose concentration level in human blood serum (3.9–7.1 mM) with a sensitivity 0.0614 μAmM−1 cm−2 and detection limit 9.6 ± 0.1 μM. This non-enzymatic glucose biosensor demonstrated excellent selectivity during the investigation of the possible impact of common interfering substances that are present in human blood. This proposed non-enzymatic glucose biosensor has also been tested for real human blood serum analysis to determine blood glucose levels showing highly motivated results. The newly designed SWCNTs-PSi/GCE biosensor exhibits excellent reproducibility and repeatability, along with long-term stability.
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