Abstract
OBJECTIVE: The sperm aster is a radial microtubule array that is organized from the sperm centrosome and that induces pronuclear apposition and syngamy in human fertilization. Cytological analyses of human eggs folllowing ICSI suggests that fertilization failure in humans can be caused by failure of sperm aster formation, even with successful oocyte activation. These reports suggest that a novel strategy is needed for treating sterility with poor sperm centrosomal function. It is reported that microinjection with motile sperm strictly selected by high power light microscopy (6,000 times) improves the pregnancy rate in couples with repeated ICSI failures.
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