Abstract
Purpose: Osteoarthritis is a common degenerative disease of the synovial joint, characterised by metabolic imbalances resulting in characteristic degradation of articular cartilage. Subsequently this causes pain, reduced mobility and inflammation. Osteoarthritis is often associated with ageing, and is a significant public health concern, with 80% of over 65-year-old being diagnosed worldwide. As a result, it is paramount to elucidate the mechanisms by which osteoarthritis develops, in order to identify potential diagnostic biomarkers and therapeutic targets.
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