Abstract
MiR-214-3p, a novel possible therapeutic target for the pathogenesis of osteoarthritis
Highlights
The destruction of articular cartilage constitutes the main feature of the disease; the structural breakdown of extracellular matrix components seems to be caused by a predominance of catabolic activities on anabolic processes of chondrocytes [2]
MicroRNA are a class of small non-coding ribonucleic acids of 22À25 nucleotides involved in the regulation of 30% of the human genome. They are involved in cell differentiation and homeostasis, and modifications of their expression have been linked to different pathological conditions including cancer, cardiovascular diseases, diabetes mellitus, rheumatic and neurological disorders [5]
214-3p in chondrocytes incubated with Interleukin-1b (IL-1b), the main cytokine implicated in OA pathogenesis. This result was strengthened by the down-regulated expression of the miR-214-3p found in damaged cartilage tissue in comparison to undamaged regions of articular cartilage obtained from human OA patients
Summary
The destruction of articular cartilage constitutes the main feature of the disease; the structural breakdown of extracellular matrix components seems to be caused by a predominance of catabolic activities on anabolic processes of chondrocytes [2]. Growing evidence demonstrated an altered expression of a number of miRNA in OA and their involvement in the regulation of cartilage homeostasis and mechanotransduction [6,7]. MiRNA can represent promising biomarkers and potential therapeutic targets of the disease.
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