Abstract
α-(3-(1-Pyridinio)-propyl)-polydimethylsiloxane iodide (PDMS-Py+I−) and α-(3-(N,N-dimethylethylammonio)-propyl)polydimethylsiloxane iodide (PDMS-Am+I−) were prepared from PDMS containing iodopropyl group at the chain end. The prepolymer was synthesized by a ring-opening polymerization of hexamethylcyclotrisiloxane (D3) initiated with lithium trimethylsilanolate followed by the termination with 3-chloropropyldimethylchlorosilane and the halogen substitution with sodium iodide. All the polymers effectively enhanced the drug penetration through the skin and the permeation coefficients were about 2–6 times as much as that without enhancer. It was revealed from the detailed analysis of the permeation profile that the permeation and partition coefficients increased in parallel, with increasing of the average degree of polymerization, while the diffusion coefficients were unchanged.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
