Abstract
To enhance the dissolution and oral absorption of poorly soluble curcumin, self-emulsifying drug delivery system (SEDDS) was developed. SEDDS is composed of oil, surfactant, and cosurfactant and evaluated for its physicochemical properties, anti-angiogenic and anti-inflammatory activity in colitis induced rat model. SEDDS formulations were characterized for enhancement in solubility, in vitro dissolution, surface morphology, IR, DSC and X-ray studies. Formulation SF-2 had shown maximum solubility and in vitro release. In addition, SF-2 was found to have angio-inhibitory activity, as demonstrated by inhibition of angiogenesis in chorioallantoin membrane assay (CAM). Anti-inflammatory activity was evaluated using DSS induced colitis rat model. Curcumin and SF-2 treated rats showed faster weight gain and the whole colon length appeared to be significantly longer than in pure curcumin and DSS treated controls. An additional finding in the DSS-treated rats was the predominance of eosinophils in the chronic cel...
Published Version
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