Abstract
Novel roles of non-coding brain RNAs in health and disease.
Highlights
Non-coding RNAs, and in particular microRNAs are rapidly becoming the focus of research interest in numerous basic and translational fields, and their importance for many aspects in brain functioning reveals novel roles and merits special discussion
To reflect the rapid recent development of ncRNA and miRNA research in the nervous system, this Research Topic eBook is focused on the search for and exploration of those ncRNAs and miRNAs whose activities modulate the multileveled functions of the eukaryotic brain in health and disease. It strives to cover the state of the art expertise and describe novel roles for known and recently identified ncRNAs and miRNAs and cover experimental approaches for identifying and establishing ncRNA-target relationships, reports of the affected pathways, inherited and acquired changes in ncRNA functioning and the use of ncRNA mimics and blockade tools for interference with their functions in health and disease
The rapidly gained reputation of miRNAs lead to escalating numbers of joint basic-clinical studies, and many of those put a major emphasis on the nervous system diseases as related to changes in miRNAs
Summary
Non-coding RNAs (ncRNAs), and in particular microRNAs (miRNAs) are rapidly becoming the focus of research interest in numerous basic and translational fields, and their importance for many aspects in brain functioning reveals novel roles and merits special discussion. The wide-scope, multi-targeted, and highly efficient manner of ncRNA regulatory activities draws attention to this topic by many, but the available research tools and experimental protocols are still insufficient, and their importance for many aspects in brain functioning keeps changing.
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