Abstract
Recent reports by the CDC have identified allograft-associated bacterial and viral infections in recipients of human allografts. There is a need for improved pathogen inactivation and terminal sterilisation of these grafts. We hypothesised that methods developed for gamma irradiation of plasma-derived therapeutic proteins could be applied successfully to a more complex biologic such as human allografts. The study included four groups of tibialis tendons: Non-irradiated controls; a group subjected to 18kGy of conventional gamma irradiation; a group subjected to 50kGy of controlled irradiation; and a group pretreated with radioprotectants prior to 50kGy of controlled irradiation. Samples were tested for tensile strength and elasticity. In addition, biochemical analysis of collagen degradation was performed on each sample.
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