Abstract
The aim of the present project work is to prepare PEGylated Anastrozole-BSA nanoparticles were prepared by desolvation technique. Prepared nanoparticles were characterized in terms of particle size, scanning electron microscope (SEM), fourier transform infraredspectroscopy (FTIR) and differential scanningcalorimetry (DSC). In-vitrorelease studies were performed in phosphate buffersaline pH 7.4 at 37˚±0.5˚C for 1month. The mean particle size of obtained nanoparticles was 150-400 nm and was apparently spherical in shape, with smooth surface. DSC is done for the stability test for pure drug and sample. The thermogram of drug has not shifted for in the formulation compare to pure drug thermogram hence, the stability of formulation is not changed . FT-IR studies demonstrated that the drug was not changed in the formulation during the fabrication process. The encapsulation efficiency was about 48%. The Anastrozole-BSA nanoparticles exhibit a most interesting release profile with small initial burst followed by slower and controlled release.
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More From: Journal of Clinical and Medical Case Reports and Reviews
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