Novel Palladium(II) and Platinum(II) Complexes with a Fluoropiperazinyl Based Ligand Exhibiting High Cytotoxicity and Anticancer ActivityIn Vitro

Randa M Bawadi,Adnan S Abu-Surrah,Kayed A Abu-Safieh,Hani D Tabba,Lubna H Tahtamouni,Fadila M Boudjelal,Huda A Almasri

doi:10.1155/2016/7508724

Randa M Bawadi, Adnan S Abu-Surrah + Show 5 more

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https://doi.org/10.1155/2016/7508724

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Abstract

cis-Dichloro-palladium(II) andcis-dichloro-platinum(II) complexes (2,4) of the general formula [M(N-N)Cl2] (M=Pd(II) and Pt(II), N-N= 1,2-diamino-4-fluoro-5-(4-methyl-1-piperazinyl) benzene, (DFMPB)) and the dicationic palladium(II) complex [Pd(N-N)(CH3CN)2](BF4)2(3) have been prepared and characterized by elemental analysis,1H-NMR-, mass spectroscopy, and IR spectroscopy. The cytotoxic effect of these complexes against MDA-231 and MCF-7 human breast cancer cell lines and K562 human leukemia cell line has been studied. The influence was dose dependent and varies with cell type. The palladium(II) complex (2) showed superior cytotoxic effect compared with the corresponding platinum(II) complex and the standard, cisplatin, when tested against all the above cell lines.

Highlights

The similarity between the coordination chemistry of palladium(II) and platinum(II) compounds has led to a large research effort towards Pd(II) antitumor drugs that are efficient against Pt(II) resistant therapies and have less side effects [1]
As an extension of our studies on both the coordination chemistry of heteroatom containing ligands [22] and the biological activity [23,24,25] of their metal complexes, we describe here the synthesis and characterization of new square-planar platinum(II) and palladium(II) complexes bearing the bidentate chelate, 1,2-diamino-4-fluoro-5-(4-methyl)-1-piperazinyl benzene (DFMPB)
The aim of our study was to investigate the influence of DFMPB as a biologically active carrier on the cytotoxic properties of the platinum(II) and palladium(II) complexes against MDA-231 and MCF-7 human breast cancer cell lines and K562 leukemia cell line

Summary

Introduction

The similarity between the coordination chemistry of palladium(II) and platinum(II) compounds has led to a large research effort towards Pd(II) antitumor drugs that are efficient against Pt(II) resistant therapies and have less side effects [1]. The hydrolysis in palladium complexes is too rapid, 105 times faster than that of the corresponding platinum analogues [2]. These complexes dissociate readily in solution leading to very reactive species that are unable to reach their pharmacological targets. If an antitumor palladium complex is to be designed, it must be stabilized by a chelate or a strongly coordinating nitrogen ligand [5]

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