Abstract
Introduction:A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligandi.e.naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction.Methods:The complexes have been characterized by elemental analysis, spectral (IR, UV–Vis, and ESR, molar conductivity, and magnetic as well as thermal analysis measurements.Results:On the basis of above studies, an octahedral geometry has been proposed for all complexes except Cu(II) nitrate complex that adopt square pyramidal geometry, and square planar geometry for Pd(II) chloride complex, respectively.Conclusion:The thermal behavior and the kinetic parameters of degradation were determined using Coats-Redfern and Horowitz-Metzger methods. Moreover, thein vitroantitumor activity of the some synthesized complexes against human breast and human hepatocarcinoma cell lines (MCF-7) and (HePG2), respectively has been studied.
Highlights
A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligand i.e. naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction
The selectivity of the macrocyclic ligands that contain combination of Oxo (O), Aza (N), Phospha (P) and Sulpha (S) for the extraction of metal ions depends on the ligand flexibility, nature of the ligand backbone, the cavity size of the macrocyclic core, nature and number of donor atoms in addition to their relative position in the macrocyclic ligands and the pendant coordinating arms attached to the ligand [8, 10]
The results indicate that Ni(II) complex (5) showed highest cytotoxic activity on both human breast cancer cell line and hepatocarcinoma cell (IC50 value = 1.6 and 1.7 μg/mL, respectively)
Summary
A new series of mononuclear Fe(II), Co(II), Ni(II), Cu(II) and Pd(II) complexes correspond to tetradentate macrocyclic nitrogen ligand i.e. naphthyl-3,4:10,11-dibenzo,7-methylene,8-methyl,6-phenyl-1,5,9,13-tetraazacyclohexadecane-5,8-diene-2,12-dione metal(II) complexes, have been synthesized by the template condensation reaction. The interest in the study of synthetic macrocyclic compounds is a very integral part of coordination chemistry due to their presence in many biological naturally occurring metal complexes. The field of macrocyclic metal chemistry is developing very rapidly because of its applications and the great importance in the coordination chemistry [1 - 12]. The importance of macrocyclic systems in chemistry is attributed to their many industrial applications and in a number of biological processes such as photosynthesis, catalytic properties, dioxygen transport and their potential application to extract specific metals [9, 10]. Complexes with poly -azamacrocyclic ligands have attracted a focus of scientific attention [7, 13].
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