Abstract
The acquisition of multiple drug resistance (MDR) phenotype is associated with the overexpression of multidrug resistance-associated genes, such as MDR1, MRP1, and BCRP. P-glycoprotein (P-gp), encoded by MDR1, is one of the most extensively characterized MDR transporters in cancer. P-gp mainly functions as a drug pump that excretes chemotherapeutic drugs from cancer cells. However, P-gp participates in cancer progression-related processes, such as cancer cell proliferation, growth, apoptosis, migration, and invasion. Several functions are independent of drug transporter activities. These data suggest that novel mechanisms are employed by P-gp to promote cancer progression. Thus, novel functions of P-gp should be understood and mechanisms by which P-gp promotes cancer aggravation should be determined to improve cancer diagnosis and treatment. In this review, recent research progress on novel contributions of P-gp to cancer progression is summarized.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call