Abstract
Novel Insights into Disseminated Candidiasis: Pathogenesis Research and Clinical Experience Converge
Highlights
Candida spp. have become leading causes of lethal bloodstream infections in countries with advanced medical technology [1]
The standard tail vein model is extremely useful because it accurately recapitulates infection introduced into patients directly through catheters, its clinical course is similar to untreated clinical disseminated candidiasis, and it has been predictive of efficacy of antifungal agents against systemic infection [3,4,5,6,7]
By far the most significant aspect of the current publication is the clever way in which the investigators sequentially disrupted specific host defense elements to determine which protected against disseminated candidiasis from a gastrointestinal source
Summary
Candida spp. have become leading causes of lethal bloodstream infections in countries with advanced medical technology [1]. These investigators have developed a novel murine model of disseminated candidiasis in which gastrointestinal colonization with C. albicans was induced. In the standard murine model of disseminated candidiasis, mice are infected via tail vein injection directly into the bloodstream.
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