Abstract
This research was undertaken with an aim to formulate dextromethorphan hydrobromide as extended release micropellets. The Preformulation studies were carried out on drug Dextromethorphane Hydrobromide and it was shows that Drug has good flow property. Various ion exchange resins were screened for complexation with the drug and ratio of drug: resin was optimized along with manufacturing process for complexation. The Drug-Resin complex was further coated with suitable hydrophobic release rate retarding polymeric coatings using fluid bed processor. Optimization of % Ethyl Cellulose coat on drug-resin complex was carried out and 23.5% EC coat was selected for preparing final batch of micropellets of the drug Dextromethorphan hydrobromide.
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