Abstract
Background and Aims: Atherosclerosis is the initiated uptake of cholesterol, mainly in an esterified form cholesteryl ester (CE) present in plasma low density lipoprotein LDL. Its initial accumulation in the intima leads to disease of the entire vessel wall and damage to the structural cells and the extracellular matrix (ECM), which regulate the mechanical properties of the vessel wall. During atherosclerosis progression, the damaged the smooth muscle cells acquire inflammatory features, with detrimental effects on vessel wall structure and function. This study applied diffusion-based MRI to investigate new linkages between the plaque lipids and vascular-tissue structural properties.
Published Version
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