Novel Biomarkers in Assessing Cardiovascular Status in Acute Myocardial Infarction

Abstract

The article is now marked as retracted from the journal, read retraction notice in Oct-Dec, 2015 Issue Introduction: The traditional risk factors for coronary heart disease do not account for the entirety of risk and there are many people who have events who do not fit into these the traditional risk factors. Aim: To assess multiple biomarkers representing in relation to cardiovascular events and to evaluate the levels of HbA1c, sialic acid, Homocysteine, high sensitive C–reactive protein in non-diabetic individual with acute myocardial infarction and possibility of their use as markers for coronary vascular events. Methods: Total 600 patients were included in the study and were divided into two groups: Group-I (cases): 300 clinically diagnosed non-diabetic myocardial infarction patients admitted in Emergency and ICCU wards. Group-II (controls): age and sex matched 300 healthy subjects with no history of diabetes mellitus and/or myocardial infarction were included. The blood samples were collected from all the cases and the control and were immediately analyzed for biochemical parameters under the study. Results: The result indicates that there is a statistically significant increase in Systolic-BP, Diastolic-BP, fasting blood glucose, HbA1c, LDL-C, sialic acid, homocysteine and Hs-CRP levels in cases as compared to control group ( Conclusion: As the concentrations of these cardiac biomarkers are increased in non-diabetic AMI subjects, it isrecommended that HbA1c, sialic acid, homocysteine and high sensitive C–reactive protein should also be included in the growing armament of biochemical cardiovascular disease markers for a better, early and more objective assessment of the disease. Keywords: Cardiovascular diseases,Myocardial infarction, HbA1c, Sialic acid, Homocysteine, High sensitive C–reactive protein.