NOVEL BIOACTIVE THIO- AND SEMICAR-BAZIDE LIGANDS AND THEIR ORGANOSILICON(IV) AND ORGANOTIN(IV) COMPLEXES

Abstract

Stereochemical and biochemical aspects of organosilicon(IV) and organotin(IV) complexes with thio- and semicarbazide ligands having NS and NO donor systems are described with the support of elemental analysis, IR, 1H, 13C NMR, 29Si NMR, 119Sn NMR and 19F NMR spectroscopy. From the analysis of these studies the donor sites of ligands are located and the geometries of donor environment around the satin(IV) and silicon(IV) acceptor centres proposed. The ligands and their metal complexes are tested in vitro and in vivo by a new technique against a number of pathogenic fungal and bacterial strains and the findings are discussed.