Abstract
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neuro-oncology, etc.
Highlights
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality with limited therapeutic options and poor outcomes
Based on the preclinical hypothesis of activity, a realistic computational simulation of human pancreatic cancer demonstrated that mean therapeutic TTFields intensities could be delivered to the site of the tumor using layouts with one pair of arrays placed on the back and front of the patient and one pair set on the lateral aspects of the patient delivered two almost perpendicular fields
Intense clinical research efforts are ongoing on several avenues in this disease, with a multitude of promising strategies on the horizon
Summary
Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality with limited therapeutic options and poor outcomes. As a result of the growing preclinical evidence, several clinical trials exploring the safety and efficacy of intravenous high-dose vitamin C for treating various types of cancers, including pancreas, have emerged either as monotherapy or in combination with chemotherapy[28]. Subsequent reports confirmed similar results in multiple pancreatic cancer cell lines and demonstrated a time and dose-dependent increase in measured H2O2 production with increased ascorbate concentrations leading to cell death with reversal of the effect with treatment with catalase[12,31].
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