Abstract
Journal of Cancer Metastasis and Treatment is an open access journal, focusing on basic and clinical studies related to cancer cell, cell biology, oncology, radiation therapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neuro-oncology, etc.
Highlights
Autophagy/macroautophagy is an evolutionarily conserved catabolic process that provides energy and macromolecular precursors through lysosomal degradation of cellular material[1,2]
Phenethyl isothiocyanate (PEITC): phenethyl isothiocyanate; ROS: reactive oxygen species; ER: estrogen receptor; AR: androgen receptor been shown that MMP2 and MMP9 proteins are both highly expressed in breast cancer tissues and are related to lymph node metastasis and tumor staging[27]
These results further prove that the regulation of miR-194 and MMP2 and MMP9 proteins is critical in cancer research and that PEITC’sability to modulate the expression of these factors is vital in the induction of autophagy and prevention of metastasis
Summary
Autophagy/macroautophagy is an evolutionarily conserved catabolic process that provides energy and macromolecular precursors through lysosomal degradation of cellular material[1,2]. Various studies have looked into the role of plant-derived phytochemicals in the autophagic response and have reported important findings in their ability to modulate this cellular process as a way to affect the development of chronic conditions including cancer[10,11,12]. PEITC exposure was shown to inhibit glycolysis, as revealed by suppressed expression of important markers including HKII, PKM2, and LDHA in LNCaP and 22Rv1 cells[23] This is a revolutionary finding, as PEITC-mediated inhibition of glycolysis in cancer cells would eliminate a major energy store for prostate cancer cells, allowing for a new type of chemotherapy, utilizing the cell’s natural autophagic response system.
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