Novel antimicrobial drugs Omadacycline Sarecycline, Eravacycline, and plazomicin: A review

Abstract

Resistance to antibiotics is a worldwide ongoing issue. Urgent want for brand new antibacterial agents has resulted in substantial studies efforts, with new molecules proposed for use in clinical practice. This review focuses on novel FDA approved antibacterial drugs (2018–2019): are new players in the area of resistant microorganism treatment. Omadacycline Sarecycline, Eravacycline, Plazomicin (2018–2019) are new healing options. This review focuses on novel FDA approved antibacterial agents (2018–2019): are new players in the field of resistant bacteria treatment. Omadacycline is a modernized tetracycline with broad-spectrum activity designed to overcome tetracycline resistance. Eravacycline is a synthetic fluorocycline antibiotic belonging to the tetracycline drug class. It disrupts bacterial protein synthesis by binding the 30S ribosomal subunit, Sarecycline is a new first-in-class tetracycline-derived antibiotic indicated for adults and children aged 9 years and older with non-nodular moderate-to-severe acne vulgaris, Plazomicin has been engineered to overcome aminoglycoside-modifying enzymes, the most common amino glycoside-resistance mechanism in Enterobacteriaceae. Despite of these new developments, there is an ongoing need and urgency to develop novel antibiotic strategies and drugs to overrun the bacterial resistance to antibiotics. Many potential signs are being investigated, broadened and confirmed by future studies. Despite recent progress, it is imperative that new antibiotic drugs and new strategies be developed to com bat antibiotic resistance.