Abstract
Vorinostat elicitation of the deep-sea fungus Talaromyces sp. HDN17-428 resulted in the isolation of one new compound, talaroenamine L (1) with unusual leptosphaeronyl moiety and three known compounds (2–4). Structures of 1–4 were confirmed by extensive NMR, HRESIMS and OR calculations. Antimicrobial activities of all compounds were tested in which compounds 1–4 showed substantial antifungal activities with MIC values ranged from 3.1 to 12.5 μM.
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