Novel and Green Preparation of Fe3O4@TiO2‐Immobilized‐ILs Based on DABCO for Highly Efficient Synthesis of Primido[4,5‐d]pyrimidines

Abstract

AbstractRecently, ionic liquids immobilized on magnetic nanoparticles (MNPs) have drawn increasing attentions in organic synthesis and separation technologies and gained substantial progresses. In this study, the Fe3O4@TiO2@ILs nanocatalyst was first synthesized and characterized by using techniques such as Fourier transform infrared spectroscopy (FT‐IR), energy‐dispersive X‐ray (EDX), vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE‐SEM), powder X‐ray diffraction (XRD), thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). The efficiency of the nanocatalyst was investigated in the preparation of pyrimido[4,5‐d]pyrimidine derivatives under solvent‐free conditions. The nanocatalyst demonstrated excellent catalytic activity and the products were synthesized in good to excellent yields. Moreover, the recoverability and reusability of the catalyst were investigated to show the effect of ionic liquid moieties on the stabilization of Fe3O4@TiO2@ILs species during the reactions. Our study showed that the nanocatalyst could be recovered and reused at least seven times without any appreciable decrease in activity which confirmed its high efficiency and high stability under the reaction conditions.