Novel alginate-amino fatty acid amide composite hybrid gel beads as nanocarriers for in vitro release of silver nanoparticles

Abstract

Nanosilver has been found to be a more effective alternative to conventional antibiotics due to its unique mechanisms of action. To facilitate prolonged topical drug delivery, a highly efficient 2,6-diaminopyridine-based silver nanocomposite gels, extended 22DAP/alginate hybrid gels and core-shell shaped hybrid gel beads are developed for prolonged topical drug delivery applications. The research revealed the benefits of in situ formation of nanosilver within the 22DAP gel and gel beads. A comparative study was conducted on silver uptake and release in a single component 22DAP gel, extended 22DAP/alginate hybrid gel, and gel beads. The study showed that the 22DAP/alginate hybrid gel beads had better efficiency of silver uptake (∼10 equivalents) due to their large surface area. These nanocomposites have also demonstrated excellent control and slow release of nanosilver, making them ideal for prolonged drug release and antimicrobial applications. The nanosilver composite 22DAP/alginate gel beads were tested against S. aureus and E. coli to evaluate their antibacterial activity, and the results were promising. The bead shape of these nanocomposites is anticipated to increase their usability for wound repair, biosensors, bone healing, and surgical interventions.