Abstract
A series of 14 novel 1,2-disubstituted benzimidazole derivatives was synthesized by reacting substituted benzimidazoles with ethyl succinyl chloride and characterized by spectroscopic techniques (FTIR, 1H NMR and Mass). The molecular docking analyses with AutoDock Tools-1.5.7 were used to examine the interactions between the compounds and the active site residues of Topoisomerase-II enzyme (PDB ID: 1JIJ). Amongst the 14 derivatives, 11 derivatives had shown greater binding affinity with the receptor in comparison with standard drug pefloxacin.
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