NOTE ON THE MULTIPLICATION AND MIGRATION OF NUCLEOLI IN NERVE CELLS OF MAMMALS

Abstract

The conclusions arrived at from the observations here described are—1. That the nucleoli of the nerve cells described multiply continually, generally by a process of budding, more rarely by an equal division in bulk of a pre‐existing nucleolus.2. That the nucleoli pass out of the nucleus, and in the process their staining reaction changes.3. After passing out of the nucleus the nucleoli become granular in appearance, and increase in size. The increase in size would appear to be due to the lessened density of the contents, rather than to an increase in substance.4. The nucleoli sometimes pass bodily out of the nerve cell (peri‐karyon), and are taken into the cytoplasm of leucocytes or capsular cells. At other times the substance of the nucleoli seems to pass in small portions from the cytoplasm of the nerve cell into that of a capsular cell or a leucocyte.