Abstract
Notch refers to a set of genes encoding a family of transmembrane receptors in mammalian cells. Previous evidence indicated that Notch receptors were implicated in the onset of gastric cancer. However, there is little evidence on the different genetic expression patterns of the four Notch receptors and their values for patient prognosis. Most recently, we investigated the transcriptional data of Notch receptors and related patient survival in patients with GC based on several databases, including ONCOMINE, GEPIA, Kaplan–Meier Plotter, cBioPortal and TIMER. According to our findings, gastric cancer tissues, compared with adjacent normal tissues presented a higher level of expression of Notch1/2/3. We also performed a survival analysis and noted that gastric cancer patients with high transcription levels of Notch1/2/3/4 had a low relapse-free survival. In gastric cancer patients, higher levels of infiltration in their CD4+ T cells, macrophages, neutrophils, and dendritic cells were positive associated with the expression of Notch receptors. Notch expression had significant association with diverse immune marker sets in gastric cancer. Overall, this study provides evidence that Notch1/2/3/4 could become the potential targets for precision treatment and new biomarkers in the prognosis of gastric cancer.
Highlights
Gastric cancer (GC) is a very common disease worldwide and has the second highest mortality rate among all cancers
We investigated the transcriptional data of Notch receptors and related patient survival in patients with GC based on several databases, including ONCOMINE, GEPIA, Kaplan–Meier Plotter, cBioPortal and TIMER
According to the information from five datasets, a significant upregulation of Notch3 mRNA expression was detected in GC patients
Summary
Gastric cancer (GC) is a very common disease worldwide and has the second highest mortality rate among all cancers. Researchers have found that the deregulated expression of specific genes can increase the risk of GC. Previous studies revealed that in GC tissues the expression of specific genes is different from that in adjacent normal tissue. Significant progress has been achieved in GC diagnosis and treatment, the five-year survival of patients is still unsatisfactory [1]. Researchers have identified epigenetic and genetic alterations as some of the main factors inducing GC. The underlying molecular pathogenic mechanisms on molecular level are still obscure. It is important to identify prognostic markers and potential drug targets to enhance prognosis and individualized treatments
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