Abstract
Chronic inflammatory disease of the nose and paranasal sinuses is most often multifactorial. Identification of cause of this disease in a given individual is frequently impractical. Moreover, if a source of inflammation can be recognized, it may not be reversible. Thus, treatment of chronic rhinosinusitis is customarily aimed at disease manifestations. Nasal endoscopy is essential to objectively assess disease and its response to medical therapy. Patients may require multiple medications for satisfactory treatment. Thus complications due to drug interactions are possible, and it is necessary to inform patients of the potential risks of therapy. This review is designed to address new developments in our understanding of the pathogenesis and medical treatment of chronic rhinosinusitis.
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