Abstract
Introduction: In islet beta cells, the endoprotease activity of prohormone convertases (PC) PC1/3 and PC2 are believed necessary for efficient processing of proinsulin to mature insulin. PC1/3 expression is a marker of beta-cell maturity and function, and polymorphisms in PC1/3 are associated with obesity, impaired glucose tolerance and elevated circulating proinsulin:insulin. Given PC1/3's key role in beta-cell function, we hypothesized that beta-cell PC1/3 deficiency would lead to beta-cell dysfunction and glucose intolerance.
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