Abstract
BackgroundNormative reference values for echocardiographic chamber quantification are of great importance; however, this can be challenging. Our aim was to derive these values including degrees of abnormality from a random Central European population sample with a homogeneous subset of healthy subjects.MethodsWe analysed echocardiograms obtained in a randomly selected population sample during the Czech post-MONICA survey in 2007/2008. Overall, 1850 out of 2273 persons of the whole sample of three districts had adequate echocardiograms (81.4%). A healthy subgroup defined by the absence of known cardiovascular disease was used to define normal reference range limits (n = 575, median age 42 years [IQR 34–52], 57% females). The whole population sample with predefined percentile cut-offs was used to define degrees of abnormality.ResultsLeft ventricular (LV) size tended to decrease with age, while LV mass increased with age in both males and females and in both the healthy and general populations. LV dimensions were larger in males, except for body surface area-indexed LV diameter. M-mode derived LV measurements were larger and LV mass higher compared to 2D measurements. Right ventricle basal dimension was larger in males.ConclusionsOur study provides reference ranges for echocardiographic measurements obtained in a healthy subgroup derived from an epidemiological study of a Central European population. Where feasible, degrees of abnormality are provided based on the whole population sample including patients with disease. Our data show that age, gender and measurement method significantly affect cardiac dimensions and function and should be always taken into account.
Highlights
Echocardiography is the most commonly used imaging method to evaluate cardiac structure and function [1]
There was a slight trend towards smaller Left ventricular (LV) size upper reference limits with increasing age
LV diameter upper reference limits decreased with age when measured using the 2D method
Summary
Echocardiography is the most commonly used imaging method to evaluate cardiac structure and function [1]. Quantification of cardiac chamber dimensions and function remains paramount to echocardiographic examination, defining normal values is of great importance. This can be challenging due to variations based on gender, age and specific populations. For defining degrees of abnormality, a true general population sample is advantageous [4, 5]. We aimed to define normal chamber dimensions and function based on a randomly selected population sample in the Czech Republic. Normative reference values for echocardiographic chamber quantification are of great importance; this can be challenging. Our aim was to derive these values including degrees of abnormality from a random Central European population sample with a homogeneous subset of healthy subjects
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