Abstract
In diabetic practice, continuous glucose monitoring (CGM) has been more used for glucose variability. Authors have reported and developed the clinical study of Low Carbohydrate Diet (LCD) and Calorie Restriction (CR) through Japan LCD Promotion Association (JLCDPA). A diabetic case is presented with normalizing glucose variability by LCD meal checked by CGM. Case is 51 years female with type 2 diabetes mellitus (T2DM). At first visit, HbA1c was 10.0%, glucose was 288mg/dL, BMI 39.1, GOT 16IU/mL, HDL-C 33mg/dL, Triglyceride 152mg/dL. CR meal was provided on day-1 to day-5 and LCD meal with 12% carbohydrate on day-6 to day-13. Average glucose value from CGM was 292mg/dL, 235mg/dL, 160mg/dL, 140mg/dL, 124mg/dL in day 3,5,7,9,11 respectively. On day-13, total Ketone bodies (T-KB) 540μmol/L (-131), Acetoacetic acid (AcAc) 86μmol/L (-55) and 3-hydroxybutyric acid (3-OHBA) 454μmol/L (-85). Weight reduction was 5kg on day-14 and 11.2kg on day-70 with BMI 34.6. Thus, LCD showed a remarkable glucose-lowering effect in short term. FreeStyle Libre (Abbott, USA) seems to be a useful apparatus for monitoring the detailed fluctuation of blood glucose. These results would become fundamental and reference data and contribute to the LCD research development in the future.
Highlights
Medical problems concerning diabetes, obesity and metabolic syndrome have been crucial and necessary to manage in many countries worldwide [1]
Large scale studies concerning the clinical effect of Low Carbohydrate Diet (LCD) was presented, such as NIPPON DATA80 (National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in the Aged 1980) Research Group and the Prospective Urban Rural Epidemiology (PURE) study [8,9]
Research development of LCD will contribute to the discussion in the future because LCD improves the average of blood glucose and Mean Amplitude of Glycemic Excursions (MAGE)
Summary
Obesity and metabolic syndrome have been crucial and necessary to manage in many countries worldwide [1]. Abbreviation: LCD: Low Carbohydrate Diet; T2DM: Type 2 Diabetes Mellitus; CR: Calorie Restriction; JLCDPA: Japan LCD Promotion Association; AcAc: Acetoacetic acid; 3-OHBA: 3-Hydroxybutyric Acid Associated with the research development of LCD, there have been some changes to the guidelines in several international diabetic societies. Research development of LCD will contribute to the discussion in the future because LCD improves the average of blood glucose and Mean Amplitude of Glycemic Excursions (MAGE).
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