Abstract
In 1937, Max Clara described a new type of cell in the human lung, which was later determined to be an exocrine secretory cell type containing granules composed of proteins [1].[...].
Highlights
In 1937, Max Clara described a new type of cell in the human lung, which was later determined to be an exocrine secretory cell type containing granules composed of proteins [1]
In 1988, in an exploratory study on proteins obtained from lung washes, Singh et al identified a protein that is expressed in both rodents and humans, which was subsequently named Clara cell 16-kDa protein (CC16) [2]
With a molecular weight of 15.8 kDa, CC16 is rapidly filtered by the glomerulus, reabsorbed almost entirely, and catabolized in the renal proximal tubule cells
Summary
In 1937, Max Clara described a new type of cell in the human lung, which was later determined to be an exocrine secretory cell type containing granules composed of proteins [1]. With a molecular weight of 15.8 kDa, CC16 is rapidly filtered by the glomerulus, reabsorbed almost entirely, and catabolized in the renal proximal tubule cells. A proximal tubular dysfunction results in the diminished resorption of CC16 and increased levels in the urine.
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