Nontuberculous Mycobacterium Infection and Tumor Necrosis Factor-α Antagonists

Reinout M Swart,Jakko Van Ingen,Jan G Den Hollander,Rob Slingerland,Willem D.H Hendriks,Dick Van Soolingen

doi:10.3201/eid1510.090110

Abstract

Nontuberculous Mycobacterium Infection and Tumor Necrosis Factor-α Antagonists

Highlights

The tuberculin skin test result was negative at screening before she began the tumor necrosis factor-α antagonist (TNF-αA) treatment, but was positive (20 mm), suggesting mycobacterial infection
Antimicrobial drug susceptibility test results for Mycobacterium haemophilum isolate from rheumatoid arthritis patient and other M. haemophilum isolates*
*All isolates submitted to the Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment (RIVM), the Netherlands, January 2000–January 2007

Summary

Introduction

The tuberculin skin test result was negative at screening before she began the TNF-αA treatment, but was positive (20 mm), suggesting mycobacterial infection. Antimicrobial drug susceptibility test results for Mycobacterium haemophilum isolate from rheumatoid arthritis patient and other M. haemophilum isolates* RIVM historic data (n = 49) % Susceptible % Resistant *All isolates submitted to the Mycobacteria Reference Laboratory, National Institute for Public Health and the Environment (RIVM), the Netherlands, January 2000–January 2007. During the follow- up period of >12 months, the patient remained asymptomatic.

Results

Conclusion