Abstract
Basal cell carcinoma is the most common nonmelanoma skin cancer. It originates from undifferentiated cells in the basal cell layer of the epidermis or from the outer root sheath of the hair follicle. The most important factor in development of basalioma is ultraviolet radiation. Surgery is considered the gold standard of treatment for basal cell cancer. However, nonsurgical options are available for individuals who are unsuitable for surgery. The purpose of this review is to summarize the efficacy and indications of alternative, nonsurgical treatments that can be used in the management of basal cell cancer
 Effective nonsurgical treatments include destructive methods (eg, curettage and electrodessication, cryosurgery, laser), photodynamic therapy, topical medications, hedgehog pathway inhibitors. Nonsurgical therapeutic alternatives are safe and effective for the treatment of BCC. Factors such as tumor location, size, and histopathological subtype should be taken into consideration when selecting optimal treatment, cosmetic results and patient preference should be considered too.
 To search for the necessary literature, the PubMed, MedLine, Web of Science and RSCI databases were used.
Highlights
Basal cell carcinoma is the most common nonmelanoma skin cancer. It originates from undifferentiated cells in the basal cell layer of the epidermis or from the outer root sheath of the hair follicle
Nonsurgical options are available for individuals who are unsuitable for surgery
The purpose of this review is to summarize the efficacy and indications of alternative, nonsurgical treatments that can be used in the management of basal cell cancer Effective nonsurgical treatments include destructive methods, photodynamic therapy, topical medications, hedgehog pathway inhibitors
Summary
Эффективные нехирургические методы лечения базальноклеточного рака кожи включают деструктивные методы (выскабливание и электродессикация, криохирургия, лазерная деструкция), фотодинамическую и наружную терапию, ингибиторы сигнального пути Hedgehog. Нехирургические альтернативы могут быть безопасны и эффективны для лечения базальноклеточного рака кожи. For citation: Kubanov AA, Saytburkhanov RR, Plakhova XI, Kondrakhina IN. Основная стратегия снижения риска развития базальноклеточного рака кожи заключается в защите от ультрафиолетового излучения, особенно в детском и подростковом возрасте. Узловой (нодулярный, язвенно-нодулярный) подтип базальноклеточного рака кожи — наиболее распространенный клинический подтип, на его долю приходится от 50 до 79% всех базалиом [10, 11]. Поверхностная базалиома — второй по распространенности клинический подтип, на который приходится до 15% всех случаев базальноклеточного рака кожи [10, 11]. ■ Североевропейское этническое происхождение ■ Светлый цвет кожи ■ Склонность к ожогам, а не к загару ■ Близость места проживания к экватору ■ Солнечные ожоги в анамнезе ■ Использование солярия
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