Abstract
The nonrenal elimination (NE), tubular reabsorption (TR) and tubular secretion (TS) of creatinine (CR) in humans and animals, especially those with normal kidney function, are often assumed to be negligible (1–6). Recent preliminary studies (4–7) indicate that the magnitude of NE, TR and TS of CR might be much greater than commonly recognized. For example, plots of renal clearance (CLr) versus the reciprocal of the (pseudo-) steady-state serum creatinine concentration yielded nonrenal clearances (CLnr) of 1.4, 8.1, 35 and 42 ml/min in 4 adult chronic renal patients studied within 6 years (4). High CLnr values were also suggested from analysis of other human studies (4).
Published Version
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