Abstract
Objective To theoretically study the non-invasive measurement method of blood hemoglobin in vivo based on the time-resolved approach combined with occlusion spectroscopy. Methods The dynamic dual wavelength time-resolved transmission was analyzed based on the artificial blood flow kinetics condition on a human finger model. The sensitivity of hemoglobin measurement was improved by Laplace transforming of time-domain data. The method was validated using hemoglobin with a mass concentration range of 6~16 g/dl. Results The simulation results showed that compared with the continuous wave method, the time-resolved method could provide higher detection sensitivity using Laplace transform parameter p=5×1010 s-1. Conclusions The sensitivity of hemoglobin measurement can be enhanced when early arriving photons are emphasized by Laplace transformingthe time-resolved transmission with a small positive parameter. Key words: Time-resolved transmission spectroscopy; Blood hemoglobin; Non-invasive measurement
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