Abstract
A noninvasive image-derived input function (IDIF) method using PET/MRI was applied to quantitative measurements of [11C] Pittsburgh compound-B (PiB) distribution volume (DV) and compared with other metrics. Fifty-three patients suspected of early dementia (71 ± 11 y) underwent 70 min [11C]PiB PET/MRI. Nineteen of them (68 ± 11 y) without head motion during the scan were enrolled in this study and compared with 16 age-matched healthy controls (CTL: 68 ± 11 y). The dynamic frames reconstructed from listmode PET data were used for DV calculation. IDIF with metabolite correction was applied to the Logan plot method, and DV was normalized into DV ratio (DVR) images using the cerebellar reference (DVRL). DVR and standardized uptake value ratio (SUVR) images were also calculated using the reference tissue graphical method (DVRr) and the 50–70 min static data with cerebellar reference, respectively. Cortical values were compared using the 3D-T1WI MRI segmentation. All patients were assigned to the early Alzheimer’s disease (eAD) group because of positive [11C]PiB accumulation. The correlations of regional values were better for DVRL vs. DVRr (r2 = 0.97) than for SUVR vs. DVRr (r2 = 0.88). However, all metrics clearly differentiated eAD from CTL with appropriate thresholds. Noninvasive quantitative [11C]PiB PET/MRI measurement provided equivalent DVRs with the two methods. SUVR images showed acceptable results despite inferior variability and image quality to DVR images.
Highlights
Molecular imaging methods are used for the clinical diagnosis of neurodegenerative diseases based on visual delineation of functional or pathological changes in the brain
Diagnostics 2020, 10, 993 volume (DV) with arterial blood samples to estimate the true input function. In comparisons of these quantitative metrics and standardized uptake values (SUV) obtained from static images in the later phase, SUV ratio (SUVR) values normalized by cerebellar cortical counts, which is usually used for the evaluation of cerebral tracer accumulation, correlated well with the distribution volume (DV) ratio (DVR) in quantitative analysis [2,3,4,5]
All metrics were compared after normalization using the cerebellar cortical values as a reference, that is, DVRs of Logan plot (DVRL) obtained from the DV image of the Logan plot, DVR from graphical reference tissue method (DVRr) calculated by the reference tissue graphical plot method, and SUVR
Summary
Molecular imaging methods are used for the clinical diagnosis of neurodegenerative diseases based on visual delineation of functional or pathological changes in the brain. Many simplified methods for evaluation of the accumulation intensity have been developed. Diagnostics 2020, 10, 993 volume (DV) with arterial blood samples to estimate the true input function. In comparisons of these quantitative metrics and standardized uptake values (SUV) obtained from static images in the later phase, SUV ratio (SUVR) values normalized by cerebellar cortical counts, which is usually used for the evaluation of cerebral tracer accumulation, correlated well with the DV ratio (DVR) in quantitative analysis [2,3,4,5]
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