Abstract
Background: Skin, the most visible human entity, quickly displays emotional, physical, and psychological well-being. Research has shown a linear correlation between both types of skin aging within 30–69 years. Thus, the current research study aimed to highlight the use of SCINEXA, the novel skin aging score, in predicting accelerated biological aging.
 Methodology: This cross-sectional study was conducted in Karachi, Pakistan, from 8th October 2021 to 4th December 2021. Both male and female subjects of age groups from 19 to 69 years were included. A novel skin aging score, 'SCINEXA' (Score of Intrinsic and Extrinsic Skin Aging), was used to assess skin aging. Both extrinsic and intrinsic signs were analyzed in terms of pigmented spots, coarse wrinkles, solar elastosis, telangiectasia, and laxity & seborrheic keratosis, respectively.
 Results: The SCINEXA score indicated that 91.3% of participants had low aging signs and decreased pigmentation, while 2.9% had relatively high pigmentation on the forehead, cheek, forearm, and back of the hand. Coarse Wrinkles of grade 5 on the forehead were present among 19.7% of individuals, and 20.6% showed the same in the crow feet area. The skin aging symptoms are most significantly associated with age (p<0.05).
 Conclusion: Accelerated biological aging is not found in the studied population using the SCINEXA tool; therefore, the studied population's skin has been found resilient to photo-aging.
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