Abstract
This editorial provides an overview and summary of recent research articles published in Biosensors journal, volumes 9 (2019) and 10 (2020), within the Special Issue “Noninvasive Early Disease Diagnosis”, which focused on recent sensors, biosensors, and clinical instruments developed for the noninvasive early detection and diagnosis of human, animal, and plant diseases or invasive pests. The six research articles included in this Special Issue provide examples of some of the latest electronic-nose (e-nose) and related volatile organic compound (VOC)-detection technologies, which are being tested and developed to improve the effectiveness and efficiency of innovative diagnostic methodologies for the early detection of particular diseases and pest infestations in living hosts, prior to symptom development.
Highlights
The Biosensors Special Issue “Noninvasive Early Disease Diagnosis” was conceived and initiated to celebrate over 30 years of electronic-sensor devices and technologies developed for disease detection in the field of clinical pathology since electronic-nose (e-nose) devices were first introduced in the mid-1980s
The study revealed no significant differences between fecal volatile organic compound (VOC)-profile patterns of refractory coeliac disease (RCD) from healthy controls, based on relatively small sample size used in this pilot study
Crohn’s disease (CD) could be discriminated from RCD and healthy controls based on fecal VOC profiles, which suggested that gas chromatography (GC)-IMS has potential as a novel tool for the detection of non-invasive VOC
Summary
The Biosensors Special Issue “Noninvasive Early Disease Diagnosis” was conceived and initiated to celebrate over 30 years of electronic-sensor devices and technologies developed for disease detection in the field of clinical pathology since electronic-nose (e-nose) devices were first introduced in the mid-1980s. Among the key advantages of electronic instruments designed to detect complex mixtures of VOC analytes in gaseous clinical samples are the capabilities of achieving noninvasive early disease detection before disease symptoms appear. The capability of classifying and characterizing gaseous chemical samples into relatively simple sensory outputs make e-noses and related electronic devices unique among diagnostic analytical instruments. These devices have the improved characteristics of simple operation, relatively low-cost, good precision, and real-time operation with high sample through-put capabilities.
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