Abstract
Non-invasive disease diagnosis through reliable detection of breath volatile organic compounds (VOCs) employing chemical sensors (the part of the electronic nose) is the central importance of the present review. VOCs (biomarkers) linked to specific disease and their concentration level above headspace has been identified and analyzed. The process of breath capture and subsequent analysis of the same has been discussed which possibly could offer a new insight to fabricate a highly integrated breath analysis system. The disease-specific biomarkers from breath or blood have been analyzed and correlated with the sensor parameter for the early detection of chronic diseases. Interference parameters such as relative humidity as well as cross-sensitivity to the nearest interfering species have been critically illustrated. Finally, the chapter concludes with various challenges associated with selectivity and the future perspective of the sensor in healthcare applications.
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