Abstract
[Figure: see text].
Highlights
Work in preclinical animal models has established that pregnancy complicated by chronic fetal hypoxia and oxidative stress programmes cardiovascular dysfunction in adult offspring
We show in rats that cardiovascular problems in male adult offspring programmed by hypoxic pregnancy can be diagnosed in vivo by analysis of blood pressure and heart rate variability, identifying noninvasive biomarkers that could be translated to the human clinical setting
We have identified noninvasive clinical biomarkers to pick up asymptomatic cardiovascular dysfunction in male adult offspring programmed by developmental hypoxia
Summary
Work in preclinical animal models has established that pregnancy complicated by chronic fetal hypoxia and oxidative stress programmes cardiovascular dysfunction in adult offspring Translating this to the human condition comes with challenges, including the early diagnosis of affected individuals to improve clinical outcomes. We show that asymptomatic cardiovascular dysfunction in adult offspring programmed by hypoxic pregnancy can be diagnosed in vivo by blood pressure variability and heart rate variability, suggesting that these noninvasive biomarkers could be translated to the clinical setting. We show in rats that cardiovascular problems in male adult offspring programmed by hypoxic pregnancy can be diagnosed in vivo by analysis of blood pressure and heart rate variability, identifying noninvasive biomarkers that could be translated to the human clinical setting. Pregnancy affected by chronic fetal hypoxia, one of the most common pregnancy complications in humans, increases the risk of cardiovascular dysfunction in later life, including hypertension
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