Abstract
DNA double-strand breaks are severe DNA lesions and are tightly related to gene amplification secondary to injury. Their repair pathways include homologous recombination(HR)and non-homologous end joining(NHEJ). NHEJ can be divided into classical non-homologous end joining(C-NHEJ)and alternative non-homologous end joining(A-NHEJ). They are relevant, but more importantly they compete with each other in most of conditions. This review briefly introduces the differences and connection between the two kinds of NHEJ in DNA recognition, processing, and ligation. And the latest progression in clinic therapy of these two kinds of DSB repair pathways. Key words: DNA double-strand breaks; Classical non-homologous end joining; Alternative non-homologous end joining
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
