Nonenzymatic glucose sensor based on icosahedron AuPd@CuO core shell nanoparticles and MWCNT

Abstract

In this paper, a novel type of icosahedron AuPd – copper oxide (CuO) core shell nanoparticles (AuPd@CuO NPs) – modified multi-walled carbon nanotubes (MWCNT) electrode for sensitive nonenzymatic glucose detection has been fabricated. AuPd@CuO core shell NPs were synthesized with icosahedron bimetallic AuPd nanocrystals as core and CuO nanoparticles (CuO NPs) as shell in a mild condition and a short time. MWCNT and AuPd@CuO NPs were characterized by field emission electron microscopy (FESEM), transmission electron microscope (TEM), energy dispersive X-ray detector (EDS) and Fourier transform infrared spectra (FT-IR). In this sensor, icosahedron AuPd@CuO NPs showed much higher electrocatalytic activity towards glucose oxidation. At an applied potential of +0.34V, this sensor showed a good sensitivity of 744.98μAmM−1cm−2 to glucose. In addition, a linear range of 3.00×10−5 to 9.31×10−3M (R2=0.997) was obtained with a detection limit of 0.10μM (S/N=3). More importantly, the AuPd@CuO NPs/MWCNT modified electrode is highly resistant against poisoning by chloride ion and inference and was used to analyze glucose concentration in human serum samples. The modified electrode exhibits an enhanced electrocatalytic property, low working potential, good sensitivity, low detection limit, excellent selectivity, and good stability towards glucose oxidation, thus the AuPd@CuO NPs/MWCNT modified electrode is promising for the future development of nonenzymatic glucose sensors.