Abstract
The ordered-fluid phase transition of phospholipid bilayers is of interest not only because it yields information on the nature of the fluid bilayer regions in biomembranes, but also because it may provide a means for triggering lateral phase separation between the ordered and fluid lipids in membranes [ 1,2]. It has been shown [3-61 that the phase transition of negatively charged lipid bilayers shows strong temperature shifts on titrating the phosphate group of the lipid polar head. This provides a way of triggering the phase transition at constant temperature by varying the pH. The free energy of the bilayer made of protonated lipids, G* = H* X.7*, changes upon deprotonation to G* GPr and this change results in a shift of the phase transition temperature from q = LUYF/LU~ to Tt , given by:
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