Abstract
The Henry (nitroaldol) reaction provides a useful method for C–C bond formation between a nitroalkane and an aldehyde or a ketone to form a β-nitro alcohol. Noncovalent interactions can play important roles in this reaction, namely by orienting the reactant molecules, lowering the reaction barriers or even building suitable supramolecular catalysts. This chapter considers the influence of noncovalent interactions (mainly H-bonding) in the Henry reaction (excluding the aza-Henry reaction) and the product selectivity including diastereoselectivity (anti or syn) and enantioselectivity.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
